Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and-2 alter morphogenesis of proximal …
M Qiu, A Bulfone, I Ghattas, JJ Meneses… - Developmental …, 1997 - Elsevier
The Dlx homeobox gene family is expressed in a complex pattern within the embryonic
craniofacial ectoderm and ectomesenchyme. A previous study established that Dlx-2 is
essential for development of proximal regions of the murine first and second branchial
arches. Here we describe the craniofacial phenotype of mice with mutations in Dlx-1 and Dlx-
1 and-2. The skeletal and soft tissue analyses of mice with Dlx-1 and Dlx-1 and-2 mutations
provide additional evidence that the Dlx genes regulate proximodistal patterning of the …
craniofacial ectoderm and ectomesenchyme. A previous study established that Dlx-2 is
essential for development of proximal regions of the murine first and second branchial
arches. Here we describe the craniofacial phenotype of mice with mutations in Dlx-1 and Dlx-
1 and-2. The skeletal and soft tissue analyses of mice with Dlx-1 and Dlx-1 and-2 mutations
provide additional evidence that the Dlx genes regulate proximodistal patterning of the …